The list of absentees is mounting up now as even at this early stage of the campaign the players are put through the ringer in various league, continental, international and increasingly pointless domestic cup competitions.
From a betting perspective, team news is undoubtedly one of the most important factors in determining bet value, so knowing your stuff is one way of levelling the playing field between you and the bookmaker.
Here’s the latest list of Premier League injuries and suspensions for the weekend of September 23-24:
West Ham vs Tottenham (Saturday, 12:30pm)
The Hammers are still without Manuel Lanzini and Pedro Obiang, who aren’t expected to return until after the next international break. James Collins is also absent with an ankle injury that looks likely to keep him out until mid-October. The big news is that Andy Carroll is fit to start his third game in a row!
Not withstanding any changes Mauricio Pochettino makes with Tuesday’s trip to Nicosia, Spurs are definitely without Danny Rose and Victor Wanyama for the next few weeks. Erik Lamela is stepping up his rehabilitation from his groin injury, and Ben Davies should have shaken off an ankle injury in time to in contention for this trip across the capital.
Burnley vs Huddersfield (Saturday, 3pm)
Tom Heaton has undergone surgery on his shoulder and will be out for the foreseeable future – young Nick Pope continues to deputise. Jonathan Walters has taken a knock to his knee and is unlikely to feature here, while Nakhi Wells and Dean Marney are definitely out.
Huddersfield have something of an attacking crisis to deal with, as Steve Mounie and Colin Quaner definitely miss out and Laurent Depoitre and Rajiv van La Parra face late fitness tests.
Everton vs Bournemouth (Saturday, 3pm)
November is the expected return date of injured trio Seamus Coleman, Ross Barkley and Yannick Bolasie, while Bruno Funes-Mori will not be seen again in a blue shirt in 2017.
There is still a long road back for Callum Wilson and Adam Federici, with December the probable return date for the crocked pair. Tyrone Mings is progressing well from a back injury, however, and is scheduled for an October return to first team action.
Manchester City vs Crystal Palace (Saturday, 3pm)
Pep Guardiola will surely rotate for the visit of hapless Crystal Palace, and the only two players he cannot select are Vincent Kompany, still battling a calf injury, and Ilkay Gundogan, whose injury misery continues. After eight months out, he picked up another knee injury on his return in midweek, and may be out for another month.
Roy Hodgson should be able to welcome back Ruben Loftus-Cheek for this tough trip north, although Wilfried Zaha and Connor Wickham are on the treatment table for the foreseeable future.
Southampton vs Manchester United (Saturday, 3pm)
Virgil van Dijk is being lined up for his long-awaited return to the Southampton starting line-up. The defender has been in exile since handing in a transfer request, but is expected to return to the first team fold shortly. Matt Targett is the Saints’ only confirmed absentee.
The extent of Paul Pogba’s hamstring injury is still unknown, although it goes without saying that he will miss this trip south. Marcos Rojo and Zlatan Ibrahimovic could provide United fans with a Christmas present as they target a December return to action.
Stoke City vs Chelsea (Saturday, 3pm)
Mark Hughes has NINE players absent from duty. You won’t see Stephen Ireland and Ibrahim Afellay for quite some time, while Ryan Shawcross, Geoff Cameron, Jakob Haugaard and Julien Ngoy are all injured and out of the Chelsea game. Kurt Zouma is unable to face his parent club, while Kevin Wimmer and Mame Diouf face late fitness tests.
Chelsea have a tough trip to Madrid on Wednesday to look ahead to, and so Antonio Conte may ring the changes. He will certainly be without Danny Drinkwater (knee), Pedro (ankle) and David Luiz (suspended).
Swansea City vs Watford (Saturday, 3pm)
The Swans are almost back to full strength, with Kyle Bartley and Sung-Yueng Ki the only long-term absentees.
We advised readers about Watford’s defensive crisis last week and Manchester City went and put six past them! The Hornets are still shy in this area with Britos, Prodl, Kaboul, Cathcart and Hoban all confirmed as out. Attacker Mauro Zarate’s absence adds to manager Marco Silva’s headache.
Leicester City vs Liverpool (Saturday, 5:30pm)
There are doubts over the fitness of Jamie Vardy, which will concern Foxes fans. The striker hasn’t trained since tweaking his groin at Huddersfield, and so a late call will be made as to whether he starts. In brighter news, Christian Fuchs is fit to return.
Sadio Mane completes the last of his three-match ban, and will be joined in the stands by Nathaniel Clyne (back) and Adam Lallana (thigh). Dejan Lovren is an injury doubt too, but Joel Matip is expected to be fit.
Brighton vs Newcastle United (Sunday, 4pm)
Brighton boss Chris Hughton is sweating on the fitness of Glenn Murray, Izzy Brown and Bruno, with Sam Baldock, Beram Kayal and Steve Sidwell out for the foreseeable future.
Newcastle’s cramped treatment room is starting to clear. Karl Darlow has returned to full fitness, meaning that Massimo Haidara and Paul Dummett are the only current incumbents on the table. Aleksandar Mitrovic’s suspensions ends after Sunday’s game.